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Research & Innovation at Spring Fertility

We are proud to participate in clinical research studies with the goal of advancing the field of reproductive medicine, improving success rates, and delivering on a higher standard of patient care.

We are actively seeking participants in several research studies, and we invite you to explore the studies below. If you qualify for and are interested in participating in any of the below studies, please contact our Clinical Research Coordinator, Trozalla Smith at [email protected]

Fertility & Reproductive Health Trials

Clinical trials are research studies that evaluate new medical approaches, devices, drugs, or other treatments. They are often used to collect data to support a hypothesis that a new and innovative method of providing care will lead to better outcomes and an improved patient experience. By participating in a clinical trial, you may be one of the first individuals to receive this new method of care.
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Luteal Support Following a
Frozen Embryo Transfer


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Mosaic and Abnormal
Embryo Transfer


Luteal Support Following a Frozen Embryo Transfer

This clinical research study will investigate the efficacy of subcutaneous progesterone injections to replace intramuscular progesterone injections and/or vaginal suppositories as the primary method of luteal support following a frozen embryo transfer. Subcutaneous injections may be preferable because they are less painful, less expensive, and less cumbersome than the existing methods. Subcutaneous injections may improve overall quality of experience for patients following an FET.




• Women planning Frozen Embryo Transfer with a genetically tested, euploid embryo made from their own egg
• At least one embryo frozen at the blastocyst stage (day 5-7) that meet Spring’s grading criteria
• Age 35-42
• Regular ovulatory menstrual cycles, defined as between 24 – 38 days in length
• BMI (Body Mass Index) < 38
• Less than 3 previous consecutive euploid blastocyst transfers without a live birth
• Procedure documenting a normal uterine cavity within the last 12 months

• Use of donor eggs or planned use of gestational carrier
• Two or more failed clinical pregnancies

• Participants will be randomly assigned to one of two treatment methods to support implantation and early pregnancy following FET
• Participation inclusive of 8 office visits, including screening and embryo transfer
• Reporting pregnancy outcome to Spring Fertility
• Financial compensation will be available for this study’s participants


If you qualify for and are interested in participating in any of the below studies, please contact our Clinical Research Coordinator, Trozolla Smith at [email protected]

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